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Studies have shown that the prevalence of erectile dysfunction (ED) increases significantly with age, affecting nearly half of all grown men in some capacity over the age of 40. Though it can certainly be a problematic condition, it’s not one that you have to resign to and accept as an unavoidable aspect of life. With avanafil, you can reclaim your sexual vitality once again.
What Is Real Avanafil?
Avanafil is classified as an oral phosphodiesterase type 5 (PDE5) inhibitor. As a PDE5 inhibitor, it is used as one of the first lines of defense against newly recognized cases of ED. Avanafil belongs to the second generation of PDE5 inhibitors in its class.
Avanafil has been approved by the US Food and Drug Administration as a safe drug to take for the reduction of ED symptoms. Though not billed as an end-all be-all treatment, as different cases of ED often stem from uniquely different circumstances, the drug has consistently been shown to be a dependable countermeasure against the majority of cases that it is used to address.
How Avanafil Works?
As a PDE5 inhibitor, Avanafil’s primary form of action is a direct effect on blood flow through vasodilation. ED is commonly the result of an inefficient volume of blood being transferred to the penis during arousal. In some circumstances, ED might also be caused by an excess amount of blood flowing out from the penis rather than flowing in.
When Avanafil is administered, the amount of blood that flows to the penis is optimized while the amount of the blood that flows out of the penis is reduced. By stimulating blood inflow and minimizing outflow, it becomes possible to achieve and maintain a full erection.
To enact its effects, Avanafil also triggers a reaction in cyclic guanosine monophosphate (cGMP) and nitric oxide. Nitric oxide and cGMP are key actors in the loosening and tightening of cavernosal muscles.
When cavernosal muscles aren’t able to relax properly, maintaining an erection becomes far more difficult. PDE5 interferes with proper cavernosal relaxation by limiting optimal levels of cGMP. A deficit of cGMP causes detumescence, and when this happens, smooth cavernosal muscles are physically incapable of relaxing in the fashion that they need to.
Avanafil facilitates higher levels of cGMP by working against the PDE5 that breaks it down, establishing the right level of physiological mediation needed for proper cavernosal muscle relaxation. The cavernosal muscles and penile blood vessels are physically restored to a state in which maintaining an erection for a natural amount of time is possible again.
The standard initial avanafil dose for an adult is 100 mg, taken orally about half an hour before sexual activity. The maintenance dose for avanafil can range between 50 mg and the maximum daily dose of 200 mg.
Generally speaking, PDE5 inhibitors tend to share a common pool of potential side effects. Most of the side effects that result from PDE5 use tend to be relatively mild in nature, though of course, different individuals may experience slightly different physiological reactions.
Some of the side effects that have been reported to occur with avanafil include:
- congestion in the nose;
- mild headaches;
- facial flushing.
Naturally, to reduce the risk of experiencing any combination of these side effects when taking avanafil, consult your primary care provider and assess how any preexisting medical conditions you have might uniquely interact with a PDE5 inhibitor. Though the side effects may not be particularly severe, it always pays to be proactive and err on the side of caution.
Like other drugs in its class, avanafil has been documented to be potentially reactive with other PDE5 medications. One of the primary medications that avanafil has been shown to interact with is sildenafil. Documented Interactions with sildenafil have primarily been subtle visual effects such as photosensitivity and slightly blurred, hued vision.
Avanafil has also been shown to have occasional interactivity with tadalafil, manifesting in effects that primarily affect the prostate and testes; none of these cross-interactive effects with tadalafil have been shown to have any inhibitory effect on reproductive capability.
As a rule of thumb, neither avanafil nor any member of the PDE5 inhibitor family should be used at the same time as a nitrate. Because the primary function of PDE5 inhibitors is to create a vasodilation effect, simultaneous nitrate use could be extremely problematic and should be refrained from whenever possible.
Avanafil has reactive potential with alpha blockers that could potentially result in orthostatic hypotension, but under the right circumstances, it is possible to concomitantly use alpha blockers and PDE5 inhibitors without adverse effects.
If you must take alpha blockers along with avanafil, then the safest course of action is to have steady and consistent alpha blocker dosages before the avanafil administration begins. Upon introducing the PDE5 inhibitor, it should only be administered at the lowest possible dose. Always speak to your doctor for advice before doing so.
Millions of men around the world have raved about the difference that avanafil has made to the quality of their sexual performance. Not only does the drug give men a second chance at performing well sexually, but its effects can also indirectly lead to a higher feeling of self-confidence.
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Is It Safe and Legal to Order Avanafil?
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